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Its clinical manifestations include motor symptoms, such as bradykinesia, resting tremor, myotonia, and postural balance disorders, and non-motor symptoms, such as hyposmia, sleep disturbance, constipation, and mental and cognitive impairment (1)
leading to a potential biochemical riboflavin deficiency worldwide ( As a matter of fact, neural tissue has a higher susceptibility to oxidative stress
3 Molecular mechanisms of oxidative stress-induced sperm damage Oxidative stress has been extensively recognized as a significant contributor to male infertility, particularly through its damaging effects on spermatozoa